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目的观察增强型体外反搏对老年2型糖尿病肾病患者早期肾脏损伤指标尿微量白蛋白(MA)、β2微球蛋白(β2-MG)、N乙酰D氨基葡萄糖酶(NAG)、尿酸(UA)、血清同型半胱氨酸(Hcy)、高敏C反应蛋白(hs-CRP)、血清胱抑素(Cys C)的影响,为老年早期糖尿病肾病的防治提供临床依据。方法选取2013年9月至2015年9月在西安交通大学第二附属医院就诊的80例老年早期2型糖尿病肾病患者,随机分成两组,对照组40例采用常规降糖药物治疗(二甲双胍+甘精胰岛素),观察组40例在上述常规治疗基础上加用增强型体外反搏治疗,均治疗8周,分别比较两组治疗前后MA、β2-MG、NAG、UA、Hcy、hs-CRP、Cys C水平的差别。结果观察组治疗8周后较治疗前MA、β2-MG、NAG、UA、Hcy、hs-CRP、Cys C水平均有明显下降(P均<0.05),且较对照组治疗8周后MA、β2-MG、NAG、UA、Hcy、hs-CRP、Cys C水平有明显下降(P均<0.05)。结论增强型体外反搏能改善老年2型糖尿病肾病患者早期肾损伤指标的水平,具有肾脏保护作用。
Objective To observe the effects of enhanced external counterpulsation on early renal injury indexes of type 2 diabetic nephropathy in elderly patients with urinary albumin (MA), β2 microglobulin (β2-MG), N-acetylglucosaminidase (NAG), uric acid (UA) , Serum homocysteine (Hcy), high-sensitivity C-reactive protein (hs-CRP), and serum cystatin (Cys C), so as to provide a clinical basis for the prevention and treatment of diabetic nephropathy in the elderly. Methods Eighty elderly patients with type 2 diabetic nephropathy who were treated in the Second Affiliated Hospital of Xi’an Jiaotong University from September 2013 to September 2015 were randomly divided into two groups. The control group was treated with conventional antidiabetic drugs (metformin + Β2-MG, NAG, UA, Hcy and hs-CRP were compared between the two groups before and after treatment for 8 weeks.All the patients in observation group were treated with enhanced EECP on the basis of the above conventional treatment, Cys C levels of difference. Results The levels of MA, β2-MG, NAG, UA, Hcy, hs-CRP and Cys C in the observation group decreased significantly after 8 weeks of treatment (all P < β2-MG, NAG, UA, Hcy, hs-CRP, Cys C levels were significantly decreased (all P <0.05). Conclusion Enhanced external counterpulsation can improve the indicators of early renal injury in elderly patients with type 2 diabetic nephropathy, with renal protective effect.