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新生儿和婴幼儿在生理上有很多特点,如身体的各种器官均处在发育之中,各种机能都不够完善,如血浆白蛋白较低,胃酸较少,生化反应中的各种酶都没有发育完全,红细胞的保护酶(葡萄糖-6-磷酸脱氢酶和谷胱甘肽还原酶)也很低下,因此,极容易发生溶血而出现黄疸。由于氯霉素要通过葡萄糖醛酸结合后形成可溶性复合物而排泄,此时,其结合酶(葡萄糖醛酰转移酶)不足,故氯霉素的排出不畅,易致中
Newborns and infants have many physiological characteristics, such as the body of various organs are in development, various functions are not perfect, such as lower plasma albumin, less stomach acid, biochemical reactions of various enzymes Are not fully developed, red cell protective enzymes (glucose-6-phosphate dehydrogenase and glutathione reductase) is also very low, therefore, extremely prone to hemolysis and jaundice. As chloramphenicol through glucuronic acid after the formation of soluble complexes and excretion, this time, the enzyme (glucuronyltransferase) is not enough, so chloramphenicol poor discharge, easy to cause moderate