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目的探讨粘着斑激酶(FAK)、尿激酶型纤溶酶原激活物(uPA)在腺样囊性癌(ACC)中的表达和相关性,及两者与腺样囊性癌的临床病理类型的关系。方法应用免疫组织化学方法检测40例唾液腺腺样囊性癌、30例多形性腺瘤和30例正常唾液腺组织中FAK、uPA的表达。结果 FAK、uPA的阳性表达率计数在正常唾液腺组织、多形性腺瘤、ACC中依次增加,组间差异具有统计学意义(P<0.05);转移组高于非转移组,神经侵犯组高于非侵犯组(P<0.05)。结论 FAK、uPA在ACC中的表达有相关性,并与ACC的临床类型密切相关,可以作为判断ACC侵袭、转移及预后的重要指标。
Objective To investigate the expression and correlation of focal adhesion kinase (FAK) and urokinase-type plasminogen activator (uPA) in adenoid cystic carcinoma (ACC) and their relationship with clinicopathological types of adenoid cystic carcinoma Relationship. Methods The expressions of FAK and uPA in 40 cases of salivary adenoid cystic carcinoma, 30 cases of pleomorphic adenoma and 30 cases of normal salivary gland were detected by immunohistochemistry. Results The positive expression rates of FAK and uPA in normal salivary gland tissues, pleomorphic adenomas and ACC were significantly higher than those in non-metastasis groups (P <0.05) Noninvasive group (P <0.05). Conclusions The expression of FAK and uPA in ACC is correlated with the clinical type of ACC, which may be used as an important index to judge the invasion, metastasis and prognosis of ACC.