应用国产旋转式伽玛刀，采用单焦点，高剂量，毁损犬脑右额叶，术后观察一般临床表现，ＭＲＩ及病理解剖变化，结果表明：犬脑经过１８０～２００Ｇｙ高剂量照射后，一般临床无明显异常改变。在６～８周内复查ＭＲＩ，在犬脑右额叶内可见一类圆形低信号区，边缘清晰，锐利。病理大体观，右额叶内可见一规整圆形毁损灶，中心呈凝固性坏死，坏死区与健康组织区的界限非常清楚，周围组织有轻度水肿。光镜下观察，毁损灶内细胞结构消失，周边水肿，有胶质细胞及毛细血管增生。 The results showed that after the high dose of 180 ~ 200Gy canine cerebrum, the normal No significant clinical changes. In 6 to 8 weeks review of MRI, a class of circular low signal area can be seen in the canine brain right frontal lobe, edge clear, sharp. The general view of the pathology, the right frontal lobe can be seen a regular round lesions, the center was coagulation necrosis, necrosis and healthy tissue area boundaries is very clear, the surrounding tissue with mild edema. Light microscope observation, the destruction of the cell structure disappeared, peripheral edema, glial cells and capillary hyperplasia.