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胃癌因早期表现较隐匿,易被忽略,发现时常常已为晚期,已失去手术治疗的机会,故疗效差、生存期短。局部复发和转移是导致胃癌患者死亡的最主要原因。近年来,腹腔内化疗(intraperitonealchemotherapy,IPC)作为进展期胃癌的辅助治疗手段之一已逐渐应用于临床,并取得了很好的疗效。随着临床治疗腹腔肿瘤技术的不断发展,腹腔灌注疗法已经被作为治疗腹腔内肿瘤的常用方式。IPC已在临床应用多年,其操作简单、使用安全、方便,该文对晚期胃癌腹腔灌注化疗的理论基础、胃癌腹腔内化疗的机制、临床特点以及常用灌注化疗药物进行总结,旨在阐明晚期胃癌腹腔内灌注化疗的发展现状。
Gastric cancer due to the earlier performance of more hidden, easily overlooked, often found late, have lost the chance of surgical treatment, so poor efficacy, short survival. Local recurrence and metastasis is the leading cause of death in patients with gastric cancer. In recent years, intraperitoneal chemotherapy (IPC) as an adjuvant treatment of advanced gastric cancer has gradually been applied to clinical and achieved good results. With the continuous development of clinical treatment of peritoneal neoplasms, intraperitoneal perfusion has been used as a common treatment for intraperitoneal tumors. IPC has been used for many years in clinical practice, its operation is simple, safe and convenient to use. This article summarizes the theoretical basis of peritoneal perfusion chemotherapy in advanced gastric cancer, the mechanism of gastric cancer intraperitoneal chemotherapy, clinical features and commonly used perfusion chemotherapy drugs to clarify the advanced gastric cancer Development of Intraperitoneal Perfusion Chemotherapy.