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内源性阿片肽（ＥｎｄｏｇｅｎｏｕｓＯｐｉｏｉｄＰｅｐｔｉｄｅ，ＥＯＰ）是心血管系统重要的调节肽。近年来发现心脏及血管壁均有ＥＯＰ及其受体的分布，提示ＥＯＰ对心血管活动的调节除中枢机制外亦存在外周机制。在缺血等应激状态下，ＥＯＰ大量释放，激动心脏阿片受体，可产生负性肌力作用和诱发心律失常，参与缺血性心脏病的发生和发展。血管壁的ＥＯＰ通过突触前和突触后机制，降低血管收缩机能，参与血压调节。阿片受体激活后的细胞内信号转导过程，涉及腺苷酸环化酶－ｃＡＭＰ系统及Ｃａ２＋，ＩＰ３，ＰＬＣ等第二信使。
Endogenous Opioid Peptide (EOP) is an important regulatory peptide in cardiovascular system. In recent years, it has been found that the distribution of EOP and its receptor in the heart and blood vessel wall, suggesting that EOP regulation of cardiovascular activity in addition to the central mechanism of the existence of peripheral mechanisms. Under isokinetic conditions such as ischemia, EOP released in large quantities and excited cardiac opioid receptors, which may produce negative inotropic effect and induce arrhythmia, which is involved in the occurrence and development of ischemic heart disease. The vascular wall EOP through presynaptic and postsynaptic mechanisms, reduce vasoconstriction, involved in blood pressure regulation. Opioid receptor activation after intracellular signal transduction involves adenylate cyclase-cAMP system and Ca2 +, IP3, PLC and other second messengers.