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目的探讨人工寒潮时不同血压水平对脑卒中发病的影响。方法360只大鼠分为寒潮和非寒潮2大组,再按血压水平各分为正常血压组、160～199mmHg、200～219mmHg和≥220mmHg等4个亚组,观察大鼠的脑卒中情况。结果脑卒中发生率在血压<220mmHg与≥220mmHg的大鼠、寒潮组与非寒潮组之间均有显著性差异。脑动脉病变严重的卒中率更高。Logistic回归发现只有寒潮前高血压是脑卒中发生的唯一独立危险因素。结论高血压、寒潮与脑卒中发病密切相关,脑动脉病变是患病基础,高血压是脑卒中的独立危险因素,而寒潮是重要的启动因子。
Objective To investigate the effects of different blood pressure levels on the incidence of stroke during artificial cold spells. Methods 360 rats were divided into two groups: cold and non-cold, and then divided into four subgroups: normal pressure group, 160 ~ 199mmHg, 200 ~ 219mmHg and ≥220mmHg according to the blood pressure level. Results The incidence of stroke in the blood pressure <220mmHg and ≥ 220mmHg of rats, cold wave group and non-cold group were significantly different. Cerebral arterial disease has a higher rate of stroke. Logistic regression found that only prehospitalization of hypertension was the only independent risk factor for stroke. Conclusion Hypertension and cold wave are closely related to the incidence of stroke. Cerebral arterial disease is the basis of the disease. Hypertension is an independent risk factor for stroke, and cold wave is an important initiating factor.