论文部分内容阅读
目的:观察紫杉醇脂质体联合顺铂治疗晚期非小细胞肺癌的近期疗效和毒副反应。方法:有可测量病灶,无法手术切除或术后复发、远处转移的40例Ⅲ～V晚期非小细胞肺癌患者,应用紫杉醇脂质体135mg/m~2第1天,顺铂25mg/m~2第1～3天。21天为1个周期,每化疗2个周期评价疗效。结果:总有效率为40%。其中初治者有效率为45.5%,复治者有效率为33.3%,两者比较有统计学差异(P<0.05)。病理类型中腺癌有效率为41.7%,鳞癌有效率为40%,两者比较无统计学差异(P>0.05)。毒副反应以骨髓抑制、胃肠道反应和周围神经毒性为主,且多为Ⅰ～Ⅱ级,患者耐受良好。
Objective: To observe the short-term curative effect and toxicity of paclitaxel liposome combined with cisplatin in the treatment of advanced non-small cell lung cancer. Methods: Forty patients with stage Ⅲ-V advanced non-small cell lung cancer who had measurable lesions that could not be surgically resected or had recurrence and distant metastasis were treated with paclitaxel liposome 135mg / m 2 on day 1, cisplatin 25mg / m ~ 2 days 1 ~ 3 days. 21 days for a cycle, evaluation of 2 cycles per chemotherapy efficacy. Results: The total effective rate was 40%. Among them, the effective rate was 45.5% in primary treatment and 33.3% in retreatment, with statistical significance (P <0.05). The effective rate of adenocarcinoma was 41.7% in pathological type and 40% in squamous cell carcinoma, there was no significant difference between them (P> 0.05). Toxicity to bone marrow suppression, gastrointestinal reactions and peripheral neurotoxicity, and mostly Ⅰ ~ Ⅱ grade, patients were well tolerated.