西咪替丁(Cimetidine,CMT)又称甲氰眯胍, 最初作为H_2受体拮抗剂用于治疗消化道溃疡、卓-艾二氏综合征、上消化道出血、返流性食道炎等,并广泛用于治疗各种皮肤病,随着对CMT的广泛研究,发现CMT有许多临床新用途,现简述如下。1.甲状旁腺机能亢进。组胺可刺激甲状旁腺激索(PTH)和环磷腺苷(cAMP)的产生,这种作用可被CMT所抑制,CMT还可使PTM肽键重新组 Cimetidine (CMT), also known as memantine, initially used as a H 2 receptor antagonist for the treatment of peptic ulcer, Zhuo-Ehrlich’s syndrome, upper gastrointestinal bleeding, reflux esophagitis and so on, And is widely used in the treatment of various skin diseases, CMT with extensive research found that CMT has many clinical uses, are summarized below. 1. Hyperparathyroidism. Histamine stimulates the production of parathyroid hormone (PTH) and cyclic adenosine monophosphate (cAMP), which can be suppressed by CMT. CMT also renders PTM peptide bonds anew