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目的探讨肺炎衣原体、肺炎支原体、幽门螺旋杆菌和柯萨奇病毒感染与高血压的关系。方法在蒙古族人群高血压现况研究基础上,选择767例高血压患者和762名血压正常者,进行病例对照研究;对研究对象有关危险因素进行问卷调查和身体指标测量,进行血脂、血糖、肺炎衣原体、肺炎支原体、幽门螺旋杆菌和柯萨奇病毒IgG抗体检测。结果病例组肺炎衣原体(40.6%)、肺炎支原体(18.3%)、幽门螺旋杆菌(56.3%)和柯萨奇病毒(41.4%)IgG抗体阳性率均分别高于对照组肺炎衣原体(36.8%)、肺炎支原体(18.0%)、幽门螺旋杆菌(53.0%)和柯萨奇病毒(40.9%)IgG抗体阳性率,但差异均无统计学意义(P>0.05);在调整心血管危险因素后,肺炎衣原体、肺炎支原体、幽门螺旋杆菌和柯萨奇病毒感染对高血压患病危险性影响差异均无统计学意义。结论肺炎衣原体、肺炎支原体、幽门螺旋杆菌、柯萨奇病毒感染与高血压危险性无明显关联。
Objective To investigate the relationship between Chlamydia pneumoniae, Mycoplasma pneumoniae, Helicobacter pylori and Coxsackie virus infection and hypertension. Methods Based on the study of the prevalence of hypertension in Mongolian population, 767 hypertensive patients and 762 normotensives were selected for case-control study. Questionnaires and body measurements were performed on the risk factors involved in the study. Blood lipids, blood glucose, Chlamydia pneumoniae, Mycoplasma pneumoniae, Helicobacter pylori and Coxsackie virus IgG antibodies. Results The positive rates of IgG antibodies against Chlamydia pneumoniae (40.6%), Mycoplasma pneumoniae (18.3%), Helicobacter pylori (56.3%) and Coxsackie virus (41.4%) were significantly higher than those of the control group (36.8% Pneumonia (18.0%), Helicobacter pylori (53.0%) and Coxsackie virus (40.9%), but the difference was not statistically significant (P> 0.05); after adjustment for cardiovascular risk factors, pneumonia Chlamydia, Mycoplasma pneumoniae, Helicobacter pylori and Coxsackie virus infection had no significant difference in the risk of hypertension. Conclusion Chlamydia pneumoniae, Mycoplasma pneumoniae, Helicobacter pylori and Coxsackie virus infection have no significant correlation with the risk of hypertension.