阿托品与东莨菪碱同为M胆碱受体阻断剂,但在以往我们的实验中,观察到对家兔皮层电活动影响颇不一致,而且两药合用,不是表现协同而是表现拮抗。为探讨两药在中枢作用方面的差异,本文报告阿托品、东莨菪碱分别与乙酰胆碱释放剂4-氨基吡啶(4-AP)合用,在皮层电活动及行为、呼吸、心率等方面的相互作用。 Atropine and scopolamine are both cholinergic receptor blockers, but in our previous experiments, we found that the effect on electrical activity of rabbit cortical was quite inconsistent, and the combination of the two drugs did not show synergies but showed antagonism. In order to explore the central role of the two drugs, we report the interaction of atropine and scopolamine with the 4-aminopyridine (4-AP), an acetylcholine releasing agent, in the cortical electrical activity and behavior, respiration and heart rate.