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目的 :观察平阳霉素 (PYM)瘤内注射治疗口腔颌面部各类淋巴管瘤 (LPGM)的疗效 ,以指导临床对不同类型LPGM采用不同的治疗方法。方法 :收集 1996年 1月至 2 0 0 3年 6月 ,用PYM注射治疗口腔颌面部毛细管型、海绵状型和囊肿型 (囊性水瘤 )淋巴管瘤 2 35例 ,男性 12 9例 ,女性 10 6例。用 1%普鲁卡因 8mL ,配PYM 8mg ,按体表瘤体面积每 1cm× 1cm注射 1mL混合药液计算剂量 ,进行瘤体内注射。 7～ 10d注射 1次 ,3～ 8次为一个疗程。结果 :经 6个月至 7年随访治愈来愈例 (85 .5 3% ) ,好转 2 4例 (10 .2 1% ) ,总有效率为 95 .74 %。其中毛细管型 ,海绵状型和囊肿型LPGM的治愈率分别为 80 .33%、88.0 0 %、93.37%。结论 :PYM治疗口腔颌面部各类LPGM疗效高 ,是一种简便、安全的有效方法
Objective: To observe the effect of intratumoral injection of PYM in the treatment of all kinds of lymphangioma (LPGM) in oral and maxillofacial region to guide clinical treatment of different types of LPGM by different methods. METHODS: From January 1996 to June 2003, 2 35 cases of oral, maxillofacial capillary, spongiform and cystic (cystic) lymphangioma were treated with PYM injection, and 129 male , 106 cases of women. With 1% procaine 8mL, with PYM 8mg, according to the body surface area of the tumor area of 1cm × 1cm injection of 1mL mixed liquid dose calculated for intratumoral injection. 7 ~ 10d injection 1, 3 to 8 times for a course of treatment. Results: After 6 months to 7 years of follow-up, more cases were cured (85.53%) and 24 cases (10.21%) were better, with a total effective rate of 95.74%. The cure rates of capillaries, spongiform and cystoid LPGM were 80.33%, 88.0% and 93.37% respectively. Conclusions: PYM is a simple, safe and effective method to treat all kinds of LPGM in oral and maxillofacial region