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对13例韦格纳肉芽肿(WG),20例特发性肺纤维化(对照)和24名正常对照者进行了支气管肺泡灌洗液(BALF)的前瞻性研究.目的①评价活动性 WG 相关肺泡炎症反应的特性;②检测 WG 患者BALF 中是否存在抗中性白细胞微抗体(ANCA),以确定是否由肺内产生;③确定吸入的微粒和感染因子是否在 WG 中起致病作用.未治的活动性 WG 患者 BALF 中性白细胞(平均占白细胞总数的42%)和嗜酸细胞(平均4%)均比正常对照(中性白细胞1.6%,嗜酸细胞0%)和未治的缓解期 WG 患者(中性白细胞5.9%,嗜酸
A prospective study of bronchoalveolar lavage fluid (BALF) was performed on 13 Wegener’s granulomatous (WG), 20 idiopathic pulmonary fibrosis (control) and 24 normal controls.Objectives ① To evaluate the activity of WG Related features of the alveolar inflammatory response; (2) detecting the presence or absence of anti-neutrophil leukocyte antibody (ANCA) in the BALF of WG patients to determine if they are produced in the lung; and (3) determining whether the inhaled particles and the infectious agent play a causative role in the WG. BALF neutrophils (averaging 42% of leukocytes in total) and eosinophils (4% on average) were significantly lower in untreated active WG patients than those in normal controls (neutrophils 1.6%, eosinophils 0%) and untreated WG remission of patients (neutrophils 5.9%, eosinophilic