克山病是一种原因尚不明,以心肌坏死为主要病变的地方性心肌病。实验病理学研究认为,克山病的心肌病变属于缺血缺氧性质。克山病病人尸检材料的电镜观察表明,心肌线粒体广泛存在着多种形式的病变。本研究室曾发现亚急性克山病死者心肌呼吸酶活性明显降低。克山病病区粮饲养动物的心肌对缺血缺氧性因素的敏感性显著增加,其氧化代谢的某些酶活性亦有改变。本文研究了克山病病区粮饲养大白鼠心肌细胞呼吸酶活性及线粒体氧 Keshan disease is a reason is not yet clear, with myocardial necrosis as the main pathological endemic cardiomyopathy. Experimental pathology that Keshan disease is a hypoxic-ischemic cardiomyopathy nature. Keshan disease patients autopsy material electron microscopy showed that there are many forms of myocardial mitochondrial lesions. The laboratory has found that subacute Keshan disease deceased myocardial respiratory enzyme activity was significantly reduced. Keshan disease ward animals fed on animal myocardial ischemia and hypoxia sensitivity was significantly increased, and some of its oxidative metabolism enzyme activity also changed. In this paper, the Keshan disease ward rat myocardial cell respiration enzyme activity and mitochondrial oxygen