应用已构建的日本血吸虫裸露ＤＮＡ疫苗ｐＣＤＳｊ３２经骨骼肌免疫小鼠，获得了较好的保护性免疫效果。１００μｇ和２００μｇｐＣＤＳｊ３２免疫后，减成虫率分别为５２．４３％和３６．４７％；肝组织减卵率分别为５４．１９％和５７．７９％；并对各组小鼠肝脏虫卵肉芽肿的面积进行了测量。结果表明，ｐＣＤＳｊ３２免疫小鼠后可减少虫荷，降低血吸虫的产卵量，抑制肝脏虫卵肉芽肿的形成。 The constructed immunized DNA vaccine pCDSj32 of Schistosoma japonicum was immunostimulated by skeletal muscle to obtain better protective immunity. 100μg and 200μg pCDSj32 immunization, the reduction of worm rates were 52.43% and 36.47% respectively; the rates of liver tissue egg reduction were 54.19% and 57.79%, respectively. The area was measured. The results showed that mice immunized with pCDSj32 could reduce the burden of worms, reduce the fecundity of schistosomiasis, and inhibit the formation of hepatic eggs granuloma.