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黄连为清热燥湿、清心除烦、泻火解毒药,其主要有效成分小檗碱具有广谱抗菌作用,临床应用较为广泛。由于药源所限,不少基层医疗单位以黄连的须根(黄连须)代替黄连应用于临床。黄连须究竟能否供药用,目前尚存有争议,且未见文献报道。鉴于这种情况,我们将黄连与黄连须分别进行了对比实验。分析实验结果证明:黄连须含有与黄连相同的主要有效成分——小檗碱,定量测得其含量在1.2%左右,约低于黄连中含量的5倍。在体外抑菌实验中,50%的黄连须煎液和10%的黄连煎液显示基本相同的结果(附表)。据以上实验结果,我们认为在临床上可考虑以黄连须入药,其剂量与黄连相比似应加大5倍,亦可从中提取小檗碱供制做片剂、注射剂或其它剂型。
Coptis is hot and damp, pure heart eliminates irritability, purging fire detoxification drugs, its main effective ingredient berberine has a broad-spectrum antibacterial effect, clinical application is more extensive. Due to the limitation of drug sources, many primary medical units use Coptis root (Coptis chinensis) in place of Coptis for clinical use. Whether Coptis is available for medicinal purposes is currently controversial and has not been reported in the literature. In view of this situation, we have conducted comparative experiments on Coptis and Coptis separately. Analysis of the experimental results shows that: Coptis contains the same main ingredient with berberine - berberine, quantitative measurement of its content of about 1.2%, about five times lower than the content of Coptis. In in vitro bacteriostatic experiments, 50% of Coptis decoction and 10% of Coptis decoction showed essentially the same results (schedule). Based on the above experimental results, we believe that taking Coptidis Rhizoma in clinical practice may be considered, and its dose should be increased by 5 times compared with Coptis chinensis, and berberine can also be extracted therefrom to make tablets, injections or other dosage forms.