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目的 探讨急性脑血管病患者血清及脑脊液中胰岛素样生长因子 - 1(IGF - 1)浓度的变化及其临床意义。方法 观察 40例脑血管病患者和 2 0例正常人血清及脑脊液IGF - 1浓度。病例组 :脑梗死组2 0例 ,脑出血组 2 0例 ,所有患者均在发病后第 3天抽取静脉血 2ml,其中脑梗死组在抽血当天作腰穿抽取脑脊液 2ml。IGF - 1采用酶联免疫分析方法测定。应用SPSS统计软件包进行统计分析 ,组间比较采用t检验。结果 病例组与对照组血清中IGF - 1浓度有明显统计学差异 (P <0 .0 1) ,脑梗死组与脑出血组血清中IGF - 1浓度无统计学差异 (P >0 .0 5 )。脑梗死组与对照组脑脊液中IGF - 1浓度有明显统计学差异 (P <0 .0 1)。结论 脑梗死和脑出血患者急性期血清IGF - 1浓度明显降低 ,脑梗死组患者急性期脑脊液IGF - 1浓度明显增高。
Objective To investigate the changes and clinical significance of insulin - like growth factor - 1 (IGF - 1) in serum and cerebrospinal fluid of patients with acute cerebrovascular disease. Methods The serum and cerebrospinal fluid concentrations of IGF - 1 in 40 patients with cerebrovascular disease and 20 normal controls were observed. Case group: 20 cases of cerebral infarction group and 20 cases of intracerebral hemorrhage group. All patients were given venous blood 2ml on the third day after onset, and 2ml of cerebrospinal fluid was withdrawn on the day of blood withdrawal in the cerebral infarction group. IGF - 1 was measured by enzyme - linked immunosorbent assay. SPSS statistical software package for statistical analysis, comparison between groups using t test. Results There was a significant difference in serum IGF - 1 levels between case group and control group (P <0.01). There was no significant difference in serum IGF - 1 levels between cerebral infarction group and cerebral hemorrhage group (P> 0.05). ). The concentration of IGF - 1 in cerebrospinal fluid in cerebral infarction group and control group was significantly different (P <0.01). Conclusion The levels of serum IGF - 1 in patients with acute cerebral infarction and cerebral hemorrhage were significantly lower than those in patients with acute cerebral infarction.