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目的探讨系统性红斑狼疮脑病(SLEE)的磁共振成像(MRI)特征和诊断价值。方法回顾性分析2007年1月-2009年7月间18例SLEE的临床表现及MRI特征。结果 18例患者MRI检查的颅脑阳性率为88.88%(16/18),脑部MRI表现为:①15例为多发病灶,局灶者1例。②双侧大脑半球、基底节区及小脑半球脑实质内长T1、长或稍长T2信号,DWI及EPI成像上呈高或稍高信号,灰白质均可受累,分布无规律性。③增强MRI扫描9例,其中5例呈斑片状强化,4例无明显强化。④脑梗死12例,脑出血4例。合并脑水肿9例,脑萎缩7例。结论 SLEE的MRI表现多样,结合临床资料,MRI可以作出诊断。
Objective To investigate the magnetic resonance imaging (MRI) features and diagnostic value of systemic lupus encephalopathy (SLEE). Methods The clinical features and MRI features of 18 patients with SLEE from January 2007 to July 2009 were analyzed retrospectively. Results The positive rate of craniocerebral in 18 patients was 88.88% (16/18). The MRI manifestations in brain were as follows: ①15 patients had multiple lesions and 1 patient had focal lesions. ② The signal intensity of T1, longer or longer T2 signals in bilateral cerebral hemispheres, basal ganglia and cerebellar hemispheres showed high or slightly higher signal on DWI and EPI images. Both gray matter and white matter may be involved and the distribution is irregular. ③ enhanced MRI scan in 9 cases, of which 5 cases were patchy enhancement, 4 cases without significant enhancement. ④ cerebral infarction in 12 cases, 4 cases of cerebral hemorrhage. 9 cases of brain edema, brain atrophy in 7 cases. Conclusion SLEE MRI performance varied, combined with clinical data, MRI can make a diagnosis.