非酒精性脂肪性肝病系遗传-代谢应激相关性疾病,其在发病机制和病理生理上因存在炎症反应、代谢紊乱和胰岛素抵抗等而与动脉粥样硬化关系密切。近来研究显示非酒精性脂肪性肝病可致动脉粥样硬化发生,在发病机制探索中,因为脂肪细胞因子在炎症、代谢和氧化应激等方面具有广泛生物学作用,故认为脂肪细胞因子可能参与作用。 Non-alcoholic fatty liver disease is a hereditary-metabolic stress-related disease, which is closely related to atherosclerosis in the pathogenesis and pathophysiology due to the presence of inflammatory reactions, metabolic disorders and insulin resistance. Recent studies have shown that non-alcoholic fatty liver disease can cause atherosclerosis, in the pathogenesis of exploration, because of adipokines in inflammation, metabolism and oxidative stress has a wide range of biological effects, it is considered that adipocytokines may be involved effect.