多环芳烃是一类在环境中广泛存在的持久性有机污染物,多数多环芳烃可通过胎盘屏障进入子代体内,经代谢活化后与DNA结合形成加合物,直接对子代的遗传物质造成损伤。此外,近期研究结果提示,宫内多环芳烃暴露还可能对子代的生长发育、免疫系统和神经系统等方面造成影响,但具体作用机制还不清楚,有待今后深入研究。 PAHs are a class of persistent organic pollutants that are widely present in the environment. Most PAHs can enter the offspring through the placental barrier and are bound to DNA to form adducts after metabolic activation, which directly affects the genetic material of the offspring Cause damage. In addition, recent findings suggest that intrauterine exposure to PAHs may also have an impact on the growth and development, immune system and nervous system of offspring, but the specific mechanism of action is not yet clear and needs further study.