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目的分析绝经后骨质疏松(OP)妇女外周血瘦素、雌激素及骨转换指标表达。方法连续选择近期就诊的35例绝经后OP患者(绝经后OP组)和30例同龄、同性别及正常骨密度的健康体检者(对照组),均接受血清瘦素(LEP)、雌二醇(E2)、卵泡刺激素(FSH)、骨钙素(BGP)和碱性磷酸酶(AKP)等指标测定。结果绝经后OP组的外周血LEP、E2浓度明显低于对照组,而血清BGP和AKP浓度则明显高于后者(P均<0.01～0.05),两组间血清FSH浓度无明显区别(P>0.05)。结论绝经后OP妇女存在着明确外周血瘦素及雌激素低水平表达,骨转换指标活跃。
Objective To analyze the expression of leptin, estrogen and bone turnover index in peripheral blood of postmenopausal women with osteoporosis (OP). Methods 35 consecutive postmenopausal OP patients (postmenopausal OP group) and 30 healthy subjects (control group) with the same age, same sex and normal BMD were enrolled in this study. Serum leptin (LEP), estradiol (E2), follicle stimulating hormone (FSH), osteocalcin (BGP) and alkaline phosphatase (AKP). Results The levels of LEP and E2 in the peripheral blood of postmenopausal OP group were significantly lower than those of the control group, but the levels of serum BGP and AKP were significantly higher than those of the latter (P <0.01-0.05). There was no significant difference between the two groups > 0.05). Conclusions There is a clear expression of leptin and estrogen in postmenopausal OP women with active bone turnover.