特定的HLA等位基因,尤其是HLA DR4抗原决定簇与牙周病的发生有关。本研究的目的旨在证实前人的结论并探讨能否通过PCR SSO来找到HLADR4抗原决定簇的亚型与牙周病易感程度的相关性。 材料和方法 ①实验设计及对象选择:实验对象中排除糖尿病患者。病例组(P组)包括48例重度牙周炎(severe periodontitis,SP)患者和12例快速进展性牙周炎(rapid progressive periodontitis,RPP)患者,共60例。年龄20～48岁;口内至少有5个不同部位的附着丧失≥6mm;至少有10个不同部位的牙 Specific HLA alleles, particularly HLA DR4 epitopes, are associated with the development of periodontal disease. The purpose of this study was to validate previous findings and to explore whether PCR SSO can be used to find the association of HLADR4 epitope determinants with susceptibility to periodontal disease. MATERIALS AND METHODS ① Experimental Design and Subject Selection: Subjects were excluded from the study. The case group (P group) consisted of 48 patients with severe periodontitis (SP) and 12 patients with rapid progressive periodontitis (RPP). Age 20 to 48 years; at least 5 different parts of the mouth of the attachment loss ≥ 6mm; at least 10 different parts of the teeth