本文对1983年日本国内发表的抗生素论文198篇和专利113份进行综述.近年来的趋势是全新的结构不多,多数是由于分离技术和仪器分析的进步,检出不少微量成分和中间体以及微生物转化的衍生物,还有特别设计的抗肿瘤物质和酶抑制剂等. This article reviews 198 articles of antibiotics and 113 patents published in Japan in 1983. The tendency in recent years is that there are not many new structures, most of which are due to the progress of separation techniques and instrumental analysis. Many minor components and intermediates are detected As well as derivatives of microbial transformation, as well as specially designed anti-tumor substances and enzyme inhibitors.