虽然麻风病在全世界不再是一个公共卫生问题,但是在一些国家和地区,麻风病的发现率仍旧没有明显下降。既往认为,麻风菌不能体外培养,缺乏对麻风菌的深入了解。基因组测序的成功,为麻风菌的分型提供依据。迄今为止,VNTR和SNP是麻风菌分型的基础,VNTR是由于核苷酸在复制过程中的滑动链错配引起,麻风菌的基因分型和麻风菌的地理分布和历史变迁有一定的关系,其中以VNTR为基础的地理分型和麻风病的短传播链有关,而且对于复发和再感染的鉴别具有积极意义。并探讨VNTR稳定性的意义。 Although leprosy is no longer a public health issue throughout the world, the prevalence of leprosy has not declined significantly in some countries. In the past that leprosy can not be cultured in vitro, the lack of a deep understanding of leprosy. The success of genome sequencing provides the basis for the typing of leprosy. To date, VNTRs and SNPs are the basis for the genotyping of leprosy. VNTRs are caused by the slip-chain mismatches of nucleotides during replication. The genotyping of leprosy and the geographical distribution and historical changes of leprosy , Where the VNTR-based geolocation is associated with a short transmission chain of leprosy and is of positive significance for the identification of relapsing and re-infection. And discuss the significance of VNTR stability.