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传染性法氏囊病是由传染性法氏囊病病毒引起禽类的一种高度传染性疾病。该病多见于雏鸡,感染雏鸡常见免疫器官萎缩,法氏囊损伤并诱导机体严重的免疫抑制,致使被感染鸡易受2次感染或免疫失败,给禽业生产带来严重的经济损失。现首先简要分析了传染性法氏囊病不同毒株基因组序列间的同源性与进化性关系,并对传染性法氏囊病病毒编码序列的microRNA靶位点进行了预测,其次探讨了microRNA与传染性法氏囊病病毒之间的调控关系,最后对microRNA在传染性法氏囊病防制中的可能应用进行展望,以期为深入研究传染性法氏囊病病毒的分子调控机制和防制提供理论参考。
Infectious bursal disease is a highly contagious disease in birds caused by the infectious bursal disease virus. The disease is more common in chickens, chickens infected with a common immune organ atrophy, bursal disease and induce severe immune suppression, resulting in infected chickens susceptible to two infections or immune failure, to the poultry industry to bring serious economic losses. At first, the homology and evolutionary relationship between the genome sequences of different IBD strains were briefly analyzed. The microRNA target sites of the infectious bursal disease virus coding sequence were predicted. Secondly, the microRNA And infectious bursal disease virus, and finally the possible application of microRNA in the prevention and treatment of infectious bursal disease is prospected in order to further study the molecular mechanism of infectious bursal disease virus and prevention System to provide theoretical reference.