缺少可识别抗原,慢性激活以及其他细胞的抑制作用,是T细胞不能有效抗肿瘤的原因。本文作者使用小鼠恶性肿瘤模型,发现肿瘤细胞对葡萄糖的消耗可以抑制T细胞功能,导致其mT OR信号通路激活抑制,糖酵解能力下降,IFN-γ分泌减少,从而促进肿瘤发生发展。作者发现,增强抑制型肿瘤糖酵解能力,可以削弱T细胞对肿瘤的抑制作用。临床中应用的针对 The lack of recognizable antigens, chronic activation and inhibition of other cells is the reason T cells are not effective against tumors. Using mouse model of malignancy, the authors found that depletion of glucose by tumor cells can inhibit T cell function, resulting in inhibition of mT OR signaling pathway, decrease of glycolysis ability, decrease of IFN-γ secretion, and promote tumor development. The authors found that enhancing inhibitory tumor glycolytic capacity can attenuate the inhibitory effect of T cells on tumors. Clinical application of targeted