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目的观察小剂量西洛他唑治疗下肢动脉硬化闭塞症早期的疗效及安全性。方法选择下肢动脉硬化闭塞症早期患者52例,予西洛他唑50mg,2次/d,治疗12周,观察并检测患者用药前后的主观症状、无痛行走距离和最大行走距离、足背动脉血管直径、峰值血流速度和血流量结果的变化。结果患者经治疗后下肢疼痛明显好转、无痛行走距离、最大行走距离有显著增加,主观症状的变化经过西洛他唑治疗12周后明显改善,足背动脉血管直径、峰值流速、血流量治疗前后差异有统计学意义(P<0.05)。结论小剂量西洛他唑治疗下肢动脉硬化闭塞症早期是有效且安全的。
Objective To observe the early efficacy and safety of low-dose cilostazol in the treatment of lower extremity arteriosclerosis obliterans. Methods Fifty-two patients with early-stage arteriosclerotic occlusive disease of lower extremity were treated with cilostazol 50 mg twice daily for 12 weeks. The subjective symptoms, painless walking distance and maximum walking distance before and after treatment were observed and measured. The dorsalis pedis artery Vascular diameter, peak blood flow velocity and changes in blood flow results. Results After treatment, the pain of lower extremity was significantly improved, the distance of painless walking and the maximum walking distance were significantly increased. Subjective symptom changes were significantly improved after cilostazol treatment for 12 weeks. The diameter of dorsalis pedis artery, peak flow velocity and blood flow volume Before and after the difference was statistically significant (P <0.05). Conclusion Low-dose cilostazol is effective and safe in the treatment of lower extremity arteriosclerosis obliterans.