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目的:探讨儿童幽门螺杆菌(Hp)感染与缺铁性贫血(IDA)的关系。方法:对155例确诊为IDA的患儿行Hp检测,将IDA伴Hp感染的患儿随机分成两组,A组35例给予铁剂治疗加抗Hp感染治疗;B组32例给予单纯铁剂治疗。观察治疗前后患儿的血红蛋白(Hb)、平均红细胞容积(MCV)、血清铁(SI)、血清铁蛋白(SF)、总铁结合力(TIBC)等血液学指标的变化。结果:155例IDA患儿中Hp阳性率43.22%(67例),Hp阳性患儿与Hp阴性患儿铁代谢指标比较差异有统计学意义(P<0.05或P<0.01),A组低于B组。A组治愈率91.43%,B组治愈率84.38%。治疗2个月后A组各贫血指标均优于B组,差异有统计学意义(P<0.05或P<0.01)。结论:儿童Hp感染与IDA之间有显著相关性,抗Hp加铁剂是治疗Hp感染相关性缺铁性贫血的有效方法。
Objective: To investigate the relationship between Helicobacter pylori (Hp) infection and iron deficiency anemia (IDA) in children. Methods: Hp was detected in 155 cases diagnosed as IDA.All children with IDA accompanied by Hp infection were randomly divided into two groups, 35 cases in group A received iron treatment plus anti-Hp infection, and 32 cases in group B received iron alone treatment. The changes of hemoglobin (Hb), mean corpuscular volume (MCV), serum iron (SI), serum ferritin (SF) and total iron binding capacity (TIBC) in children before and after treatment were observed. Results: The positive rate of Hp was 43.22% (67 cases) in 155 cases of IDA. The difference of iron metabolism between Hp-positive children and Hp-negative children was statistically significant (P <0.05 or P <0.01) Group B. The cure rate of group A was 91.43%, the cure rate of group B was 84.38%. After 2 months of treatment, the indicators of anemia in group A were better than those in group B, the difference was statistically significant (P <0.05 or P <0.01). Conclusion: There is a significant correlation between Hp infection and IDA in children. Anti-Hp and iron supplementation are effective methods to treat Hp-related iron deficiency anemia.