目的观察加味四君子汤和思密达改善小鼠肠黏膜屏障的作用。方法盐酸林可霉素灌胃建立小鼠肠黏膜破损及肠道菌群失调模型。昆明种鼠随机分5组,进行肠道菌群检测、细菌易位分析及通透性(血浆二胺氧化酶)的检测。结果盐酸林可霉素灌服小鼠3 d,肠道菌群失调、细菌平均易位率从正常对照组的12.5%增加到59%,血浆二胺氧化酶从正常对照组的2.08 mg/ml增加到7.18 mg/ml,肠黏膜屏障功能受损。分组分别给加味四君子汤、思密达后,肠道菌群得以调整,细菌平均易位率降低到9.35%以下,血浆二胺氧化酶减低到3.88 mg/ml以下。结论加味四君子汤和思密达均能调整失调的菌群、降低肠道通透性和细菌易位率,改善小鼠肠黏膜屏障功能。 Objective To observe the effects of Jiawei Sijunzi Decoction and Smecta on improving the intestinal mucosal barrier in mice. Methods The intestinal mucosal damage and the intestinal dysbacteriosis model were established by intragastric administration of lincomycin hydrochloride. Kunming mice were randomly divided into 5 groups for intestinal flora detection, bacterial translocation analysis and permeability (plasma diamine oxidase) detection. Results The mice were orally administered with lincomycin hydrochloride for 3 d. The intestinal dysbacteriosis and the average bacterial translocation rate increased from 12.5% ​​in the normal control group to 59%. The plasma diamine oxidase was 2.08 mg/ml in the normal control group. Increased to 7.18 mg/ml, impaired intestinal mucosal barrier function. Subsequent to the addition of flavored Sijunzitang and Smecta, the intestinal flora was adjusted, the average translocation rate of bacteria was reduced to 9.35% or less, and plasma diamine oxidase was reduced to 3.88 mg/ml or less. Conclusion Both Modified Sijunzi Decoction and Smecta can adjust dysbacteriosis, reduce intestinal permeability and bacterial translocation rate, and improve intestinal mucosal barrier function in mice.