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目的分析老年肺结核应用抗结核病药物治疗的不良反应及其影响因素。方法随访调查92例老年肺结核患者应用抗结核病药物治疗引起的不良反应,分析其不良反应影响因素。结果 1大多数患者存在胃肠道反应、神经损害、过敏反应与肝损害,极少数患者发生骨关节损害、血液异常以及其他不良反应。2本组患者不良反应药物集中在链霉素、异烟肼(H)、利福平(R)、吡嗪酰胺(Z),分别占30.16%、33.70%、38.04%、63.04%。3经单因素分析:男女患者不良反应发生情况比较差异无统计学意义(P>0.05),有无肝病史、不同治疗类型、不同诊断类型、不同体质量指数(BMI)、不同年龄间不良反应发生情况比较差异具有统计学意义(P<0.05)。4多因素分析有肝病史与高龄是抗结核药物相关不良反应的独立危险因素(P<0.05)。结论抗结核病药物不良反应发生率较高,而有肝病史患者与高龄患者发生不良反应的几率更高。
Objective To analyze the adverse reactions and their influencing factors of anti-tuberculosis drug treatment in senile pulmonary tuberculosis. Methods Follow-up survey of 92 elderly patients with pulmonary tuberculosis treated with anti-tuberculosis drug-induced adverse reactions, analysis of the adverse reaction factors. Results Most patients had gastrointestinal reactions, nerve damage, allergic reaction and liver damage, and very few patients suffered from bone and joint damage, blood abnormalities and other adverse reactions. Adverse reactions in this group of patients focused on streptomycin, isoniazid (H), rifampin (R), pyrazinamide (Z), accounting for 30.16%, 33.70%, 38.04%, 63.04%. Univariate analysis showed that there was no significant difference in adverse reactions between male and female patients (P> 0.05), with or without history of liver disease, different treatment types, different diagnosis types, different body mass index (BMI), adverse reactions The incidence of difference was statistically significant (P <0.05). 4 Multivariate analysis had a history of liver disease and aging is an independent risk factor for adverse reactions associated with anti-TB drugs (P <0.05). Conclusion The incidence of adverse drug reactions to anti-tuberculosis drugs is high, while patients with history of liver disease have a higher risk of adverse reactions.