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一、概况 1.利福霉素类抗菌素的发现及其微生物来源利福霉素类抗菌素是1957年意大利Lepetit公司从法国土壤中分离的地中海链丝菌(Streptomyces mediterranei)产生得到的抗菌素。他们费了四年时间,收集了世界各地2000只土壤标本,从链丝菌中分离了18,000株,由此选出了产生菌,发现该产生菌的发酵液对革兰氏阳性菌及结核分枝杆菌具有强的杀菌作用。产生菌在含有巴比妥酸衍生物培养基中得到的培养液经纸上层析,分离得到A、B、C、D、E五种成份,仅利福霉素B得到了结晶,是稳定的物质,毒性低。1964年日本找到了产生利福霉素O的产生菌。利福霉素B很容易转变
I. Overview 1. The discovery of rifamycin antibiotics and its microbial origin Rifamycins antibiotics are antibiotics produced by Streptomyces mediterranei isolated in 1957 by Lepetit Italia from French soils. They spent four years collecting 2000 soil samples from around the world and isolating 18,000 strains from the streptomyces strains, thus selecting the producing bacteria, and found that the fermentation broth of the producing bacteria had a positive effect on Gram-positive bacteria and tuberculosis Mycobacteria have a strong bactericidal effect. Producing bacteria in the culture medium containing barbituric acid derivative obtained by chromatography on paper, isolated A, B, C, D, E five ingredients, only rifamycin B has been crystallized, is stable The substance, low toxicity. In 1964 Japan found rifamycin O producing bacteria. Rifamycin B is easy to change