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1例58岁女性2型糖尿病患者应用盐酸二甲双胍(0.5 g,2次/d口服)及胰岛素(三餐前分别皮下注射胰岛素8、8、10 U,睡前皮下注射甘精胰岛素8 U)治疗,因效果不佳加用西格列汀(100 mg,1次/d口服)。3周后,患者出现恶心、呕吐伴腹痛。实验室检查:血清淀粉酶499 U/L,尿淀粉酶933 U/L。腹部超声检查示腹腔积液。诊断为急性胰腺炎。停用西格列汀、盐酸二甲双胍,继续应用胰岛素,并给予抑酸、抑酶、补液等治疗。6 d后,患者病情好转,血清淀粉酶76 U/L,尿淀粉酶288 U/L。
A 58-year-old female with type 2 diabetes mellitus was treated with metformin hydrochloride (0.5 g twice daily) and insulin (8, 8 and 10 U insulin subcutaneous injection before meals and 8 g insulin glargine at bedtime) , Due to ineffective plus sitagliptin (100 mg, 1 / d orally). Three weeks later, the patient developed nausea and vomiting with abdominal pain. Laboratory tests: serum amylase 499 U / L, urinary amylase 933 U / L. Abdominal ultrasonography showed celiac effusion. Diagnosis of acute pancreatitis. Stop the use of sitagliptin, metformin hydrochloride, continue to use insulin, and given acid suppression, inhibition of enzyme, rehydration therapy. After 6 days, the patient’s condition improved, serum amylase 76 U / L, urine amylase 288 U / L.