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目的研究丙氨酰谷氨酰胺在有创机械通气患者营养支持中的作用。方法32例机械通气患者随机分为研究组(17例)和对照组(15例),在机械通气后的第2~11d,在常规治疗的基础上,分别给予10d的等氮等热量肠外营养支持,其中研究组加入丙氨酰谷氨酰胺,对照组予常规营养支持。统计分析两组ICU住院时间、机械通气时间、呼吸机相关肺炎发生率、28d病死率。结果营养支持10d后研究组ICU住院时间、机械通气时间、呼吸机相关肺炎发生率均比对照组降低(P<0.05),差异有统计学意义,研究组28d死亡率较对照组下降,但差异无统计学意义(P<0.05)。结论丙氨酰谷氨酰胺能有效减少有创机械通气患者的ICU住院时间及机械通气时间,降低呼吸机相关肺炎发生率。
Objective To investigate the role of alanylglutamine in nutritional support in patients with invasive mechanical ventilation. Methods 32 patients with mechanical ventilation were randomly divided into study group (n = 17) and control group (n = 15). On the second to eleventh day after mechanical ventilation, on the basis of routine treatment, Nutritional support, including the study group added alanyl glutamine, the control group to conventional nutritional support. Statistical analysis of hospital ICU length of stay, mechanical ventilation time, the incidence of ventilator-associated pneumonia, 28d mortality. Results After 10 days of nutritional support, ICU hospitalization time, mechanical ventilation time and ventilator-associated pneumonia incidence in study group were significantly lower than those in control group (P <0.05), and the difference was statistically significant. The 28-day mortality rate in study group was lower than that in control group, Not statistically significant (P <0.05). Conclusions Alanylglutamine can effectively reduce ICU length of stay and mechanical ventilation in patients with invasive mechanical ventilation and reduce the incidence of ventilator-associated pneumonia.