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出血和感染是骨髓抑制病人死亡的主要原因。虽然输入血小板能够控制出血,但感染仍然是个大问题,因为粒细胞减少症病人抗生素疗效减低。在混合淋巴细胞(LD抗原)反应中,可以鉴别移植物抗宿主(GVH)和宿主抗移植物(HVG)反应的免疫原。这种可能性在巨噬细胞中不存在。当巨噬细胞输入LD不相容的个体时,巨噬细胞存活的时间要比粒细胞长。来自腹膜的巨噬细胞与来自肺泡和脾脏的巨噬细胞之间存在着巨大差异,腹膜巨噬细胞表现为弱或不能检出的淋巴细胞抗原,并富含
Bleeding and infection are the major causes of death in patients with myelosuppression. Although the introduction of platelets can control bleeding, infection is still a big problem because of the reduced efficacy of antibiotics in patients with neutropenia. In mixed lymphocyte (LD antigen) reactions, immunogens that recognize both graft versus host (GVH) and host anti-graft (HVG) responses can be identified. This possibility does not exist in macrophages. When macrophages enter LD-incompatible individuals, macrophages survive longer than granulocytes. There is a huge difference between peritoneal macrophages and alveolar and spleen-derived macrophages, which show weak or undetectable lymphocyte antigens and are abundant