抵抗素是存在于血浆中的富含半胱氨酸的分泌性蛋白,属于抵抗素样分子家族,又称脂肪组织特异性分泌因子。其与胰岛素抵抗及炎症等关系密切。非酒精性脂肪性肝病(NAFLD)代表了一组以甘油三酯在肝内过度贮积而引起的临床病理综合征,目前认为其属于代谢综合征的范畴,胰岛素抵抗及炎症因子的参与是其发病的重要环节。深入研究抵抗素与胰岛素抵抗及炎症的关系将有助于进一步了解NAFLD的发病机制,为寻求合理的治疗方案提供理论依据。 Resistin is a cysteine-rich secreted protein found in plasma and belongs to the family of resistin-like molecules, also called adipose tissue-specific secretory factor. It is closely related to insulin resistance and inflammation. Non-alcoholic fatty liver disease (NAFLD) represents a group of clinicopathological syndromes caused by excessive storage of triglycerides in the liver and is currently considered to belong to the category of metabolic syndrome. Insulin resistance and inflammatory cytokines are involved An important part of the disease. Further study of the relationship between resistin and insulin resistance and inflammation will help to further understand the pathogenesis of NAFLD and provide a theoretical basis for seeking a reasonable treatment plan.