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目的观察根除幽门螺杆菌治疗对高原地区幽门螺杆菌相关性溃疡病患者血清IL-1β、IL-2、IL-4、IL-6、IL-8和TNF水平的影响,以探讨其在溃疡病发病中的可能致病机理。方法应用放射免疫法测定55例溃疡病患者血清6种细胞因子的含量,比较幽门螺杆菌感染与非感染患者含量的差异,对幽门螺杆菌感染患者进行以洛赛克为中心的三联1周疗法,比较根除前后及根除者和未根除者其含量的差异,同时比较幽门螺杆菌根除组和未根除组溃疡的愈合率。结果55例患者中,幽门螺杆菌感染者30例,感染者血清IL-4含量明显低于非感染者(P<0.01),幽门螺杆菌根除后其含量极明显高于根除前(P<0.001),未根除者前后比较无变化(P>0.05),根除者明显高于未根除者(P<0.05),而根除幽门螺杆菌治疗对IL-1β、IL-2、IL-6、IL-8和TNF均无显著性影响(P>0.05),幽门螺杆菌根除组溃疡愈合率明显高于未根除组(P<0.05)。结论幽门螺杆菌感染后IL-4降低导致的Th2免疫应答下调可能是幽门螺杆菌相关性溃疡病发生的主要致病机制之一;根除幽门螺杆菌可使IL-4分泌明显增加,Th2免疫应答上调,从而加速溃疡愈合;血清IL-4的检测有望成为根除幽门螺杆菌和溃疡愈合疗效判定的有用指标。
Objective To observe the effects of Helicobacter pylori eradication on the levels of IL-1β, IL-2, IL-4, IL-6, IL-8 and TNF in patients with Helicobacter pylori- Pathogenesis may be pathogenesis. Methods The serum levels of six cytokines in 55 cases of ulcer patients were determined by radioimmunoassay. The differences of Helicobacter pylori infection and non-infected patients were compared. The patients with Helicobacter pylori infection were treated with Losec-centered triple therapy for one week The etiological factors of ulcer in Helicobacter pylori eradication group and non-eradication group were compared before and after eradication, eradication and eradication. Results Among the 55 patients, there were 30 cases of Helicobacter pylori infection and the levels of IL-4 in the infected patients were significantly lower than those in the non-infected patients (P <0.01). The content of Helicobacter pylori eradication was significantly higher than that before eradication (P0.001) The levels of IL-1β, IL-2, IL-6 and IL-6 in eradication group were significantly higher than those in non-eradication group (P <0.05) 8 and TNF (P> 0.05). The healing rate of H.pylori eradication group was significantly higher than that of non-eradication group (P <0.05). Conclusion The down-regulation of Th2 immune response induced by Helicobacter pylori infection may be one of the main pathogenic mechanisms of H. pylori-related ulcer disease. Eradication of Helicobacter pylori can significantly increase the secretion of IL-4 and Th2 immune response Increased, thus accelerating the healing of ulcer; serum IL-4 detection is expected to become a useful indicator of the eradication of Helicobacter pylori and ulcer healing.