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氨联吡啶酮对左室有正性肌力和血管扩张作用,可改善心衰病人血动力学。但其对右室作用尚未进行广泛研究,为此,本文作者进行氨联吡啶酮对右室功能作用的探讨。作者对9例重度心衰病人(4例充血型心肌病,5例冠心病),年龄26～72岁。以短时间静脉注射氨联吡啶酮,用放射性核素心室造影研究右室收缩末期压力-容量关系,以确定右室收缩功能改善系右室前负荷的减少,抑或系收缩性增加所致,每例病人先给不同剂量硝普盐,继静脉注射氨联吡啶酮3毫克/公斤。结果:全部病例肺血管阻力(38±6%,P<0.01)减少,其中8例肺动脉收缩末期压力(23±11%,P<0.01)也减少;右室收缩末期容量减少(23±8%,P<0.01);右室射血分数增加(31±10%,P=0.01)。
Ampicillin on the left ventricular positive inotropic and vasodilator effect, can improve hemodynamic in patients with heart failure. However, its role in the right ventricle has not been extensively studied. For this reason, the author of this article discusses the effect of aminopyridone on right ventricular function. The authors of 9 cases of severe heart failure patients (4 cases of congestive cardiomyopathy, 5 cases of coronary heart disease), aged 26 to 72 years. In a short time intravenous aminopyridone, radionuclide ventriculography study the relationship between right ventricular end-systolic pressure - capacity to determine the right ventricular systolic function to improve the Department of right ventricular preload reduction, or systolic increase caused by each Example patients give different doses of nitroprusside, following intravenous aminopyridone 3 mg / kg. Results: Pulmonary vascular resistance (38 ± 6%, P <0.01) decreased in all cases. The end systolic pressure of 8 patients (23 ± 11%, P <0.01) , P <0.01); right ventricular ejection fraction increased (31 ± 10%, P = 0.01).