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一、概述各种细胞可受不同种的病毒感染后而产生干扰素.干扰素须进入另一细胞才能发挥抗病毒作用.干扰素除可由病毒诱导外,也可由一些二级结构稳定的聚合核苷酸作用而产生.其中一种较强的诱导剂即双股 RNA 的 PolyI:C.此外,T 细胞和一部分B 细胞受促分裂素作用后亦可产生干扰素,后者是一种淋巴因子。还有一大组种类繁多的因子亦可在一些细胞中诱导干扰素,特别是巨噬细胞.受病毒感染后可能就在病毒复制过程中形成的双股 RNA是干扰素最重要的诱导剂.从分子水平上来探讨诱导干扰素确切的机制,目前尚未阐明,但已知这种刺激可使细胞核转录干扰素的 mRNA.人的第5对染色体有编码干扰索的 mRNA 部分。在胞浆内 mRNA
First, an overview of a variety of cells can be infected by different types of viruses and produce interferon. Interferon must enter another cell to play an antiviral effect.In addition to interferon can be induced by the virus, but also by a number of stable secondary polymerization nuclei One of a strong inducer that double-stranded RNA PolyI: C. In addition, T cells and some B cells by mitogen can also produce interferon, which is a lymphokine . There is also a large group of a wide variety of factors that can also induce interferons, especially macrophages, in some cells.The double-stranded RNA, which may be formed during virus replication after being infected by a virus, is the most important inducer of interferon. At molecular level, the exact mechanism by which interferon is induced is not currently elucidated, but it is known that this stimulation causes the nucleus to transcribe interferon mRNA, and human chromosome 5 has a portion of the mRNA encoding the interfering RNA. In cytoplasmic mRNA