目的探讨电子止吐仪干预改善吗啡缓释片所致恶心呕吐等消化系统不良反应的临床疗效。方法选取癌痛程度为中重度的恶性肿瘤患者80例,随机分成对照组和观察组,每组40例,两组患者治疗前均无明显消化系统症状。对照组单独服用吗啡缓释片,观察组服用吗啡缓释片的同时持续使用电子止吐仪,比较治疗1周内两组患者在恶心、呕吐、便秘、卡氏功能状态(KPS)评分、疲劳、焦虑及食欲等方面的差异。结果观察组和对照组第1~7天Ⅱ-Ⅳ度恶心呕吐的发生率分别为2.5%对7.5%、5.0%对20.0%、5.0%对22.5%、7.5%对25.0%、10.0%对27.5%、0.0%对7.5%及0.0%对5.0%,两组第2~5天各天恶心呕吐的发生率差异均具有统计学意义(P<0.05);因恶心呕吐反应明显,对照组停药2例,观察组无停药病例。观察组和对照组的便秘发生率、KPS评分改善率、疲劳改善率、焦虑改善率及食欲改善率分别为67.5%和72.5%、57.5%和22.5%、52.5%和25.0%、62.5%和35.0%及52.5%和27.5%(P<0.05),除便秘发生率外,两组上述各项指标发生率组间差异均有统计学意义(P<0.05)。结论电子止吐仪可显著改善吗啡缓释片所致恶心呕吐等不良反应,提高患者的生存质量,且未见新增其他严重不良反应。 Objective To investigate the clinical efficacy of electronic antiemetic device in improving the adverse reactions of digestive system such as nausea and vomiting caused by morphine sustained-release tablets. Methods Eighty patients with malignant tumor with moderate or severe degree of cancer pain were randomly divided into control group and observation group with 40 cases in each group. There were no obvious digestive symptoms in both groups before treatment. The patients in the control group took morphine sustained-release tablets alone and the observation group took morphine sustained-release tablets while continuing to use electronic antiemetic devices. The patients in the two groups were treated with nausea, vomiting, constipation, KPS score, fatigue , Anxiety and appetite and other differences. Results The incidence of grade II-IV nausea and vomiting in observation group and control group were 2.5% vs 7.5%, 5.0% vs 20.0%, 5.0% vs 22.5%, 7.5% vs 25.0%, 10.0% vs 27.5 %, 0.0% vs 7.5%, and 0.0% vs 5.0% respectively. There was significant difference in the incidence of nausea and vomiting between day 2 and day 5 (P <0.05). Because of the obvious reaction of nausea and vomiting, 2 cases, observation group without stopping cases. The incidences of constipation, KPS improvement, fatigue improvement, anxiety improvement and appetite improvement in observation group and control group were 67.5% and 72.5%, 57.5% and 22.5%, 52.5% and 25.0%, 62.5% and 35.0% respectively %, 52.5% and 27.5%, respectively (P <0.05). Except for the incidence of constipation, there were significant differences between the two groups in the incidence of these indicators (P <0.05). Conclusion Electronic antiemetic device can significantly improve the nausea and vomiting caused by morphine sustained release tablets and other adverse reactions, improve the quality of life of patients, and no other serious adverse reactions.