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目的:探讨血浆同型半胱氨酸与急性冠状动脉综合征(ACS)发作期和自身缓解期的相关性。方法:对64例ACS患者的发作期和自身缓解期及64例对照组分别测定血浆同型半胱氨酸浓度并进行比较,同时测定C-反应蛋白对照观察。结果:ACS发作期血浆同型半胱氨酸水平[(26.72±3.2)μmol/L]显著高于对照组[(8.94±2.1)μmol/L]和自身缓解期[(17.88±2.8)μmol/L],均P<0.01。血浆C-反应蛋白在ACS发作期[(14.54±3.1)mg/L]与对照组[(4.36±1.8)mg/L]比较差异有统计学意义(P<0.01)。与自身缓解期[(13.72±5.3)mg/L]比较,则(P>0.05)。结论:ACS患者发作期血浆同型半胱氨酸水平与ACS的发生有关,是动脉粥样硬化斑块不稳定的标志;C-反应蛋白对动脉粥样硬化斑块不稳定性的预测比同型半胱氨酸差。
Objective: To investigate the correlation between plasma homocysteine and acute coronary syndrome (ACS) onset and remission. Methods: Plasma homocysteine concentrations were measured in 64 ACS patients during the onset and remission period and 64 control subjects respectively. Plasma concentrations of homocysteine were measured and compared with C-reactive protein control. Results: The plasma homocysteine level in ACS onset was significantly higher than that in control group ([(26.72 ± 3.2) μmol / L vs (8.94 ± 2.1) μmol / L and (17.88 ± 2.8) μmol / L vs ], All P <0.01. There was significant difference in the plasma C-reactive protein between the ACS onset ([14.54 ± 3.1] mg / L] and the control group (4.36 ± 1.8 mg / L) (P <0.01). Compared with self-remission [(13.72 ± 5.3) mg / L] (P> 0.05). Conclusions: Plasma homocysteine level in ACS patients is related to the occurrence of ACS, which is a marker of atherosclerotic plaque instability. C-reactive protein is more predictive of atherosclerotic plaque instability than that of homozygous Cystine poor.