口服硫酸镁溶液致严重过敏反应1例

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1临床资料患者,女,22岁,主诉无药物过敏史。2013年6月3日因便血3 d就诊于我院消化内科,拟于6月4日进行肠镜检查。患者6月3日18时首次服用“50%硫酸镁溶液”60 ml,21时再次服用“50%硫酸镁溶液”60 ml。患者诉,服药期间遵医嘱大量喝水,并大便2~3次,但第二次服用“硫酸镁溶液”后约20 min,出现恶寒寒颤,发热,头晕头痛,四肢乏力。随即家人送患者至我院急诊,体温39.7℃,面色苍白,呼吸困难,胸闷,咽红充血明显,查血常规:WBC 8.6×109个/L,中性细胞比率86.34%,电解质:K+3.26 mmol·L-1,余未见明显异常。诊断为:药源性发热;过敏性休克;低钾血 1 clinical data patients, female, 22 years old, the main complaint no history of drug allergy. June 3, 2013 due to blood in the stool 3 d in our hospital digestive medicine intends to conduct colonoscopy on June 4. Patients at 18:00 on June 3 for the first time taking “50% magnesium sulfate solution ” 60 ml, 21:00 again taking “50% magnesium sulfate solution ” 60 ml. Patients complained that during the medication prescribed by a doctor a lot of water, and stool 2 or 3 times, but the second taking “magnesium sulfate solution ” after about 20 min, aversion to chills, fever, dizziness, headache, limb weakness. Then the family sent patients to our hospital emergency room, body temperature 39.7 ℃, pale, dyspnea, chest tightness, pharyngeal congestion was obvious, check the blood routine: WBC 8.6 × 109 / L, 86.34% neutral cell ratio, electrolyte: K +3.26 mmol·L-1, I no obvious abnormalities. Diagnosed as: drug-induced fever; anaphylactic shock; hypokalemia
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