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炎症性肠病(IBD)是一种终身性的反复发作的肠道炎症性疾病,包括溃疡性结肠炎(UC)与Crohn病(CD)。IBD的传统治疗方法之一是免疫抑制剂治疗,该疗法可使许多IBD患者病情达到长期缓解效果,因此,被临床广泛应用。免疫抑制剂包括硫唑嘌呤、6-巯基嘌呤、环孢霉素A、氨甲蝶呤等。随着免疫抑制剂的广泛使用,其毒副作用日渐暴露,免疫抑制剂相关淋巴瘤的案例越来越多。本文综述了免疫抑制剂治疗IBD与淋巴瘤发生关系、可能机制及免疫抑制剂临床治疗参考。
Inflammatory bowel disease (IBD) is a life-long recurrent inflammatory bowel disease that includes ulcerative colitis (UC) and Crohn’s disease (CD). One of the traditional treatment of IBD is immunosuppressive therapy, which can make long-term relief of the disease in many IBD patients and is therefore widely used clinically. Immunosuppressive agents include azathioprine, 6-mercaptopurine, cyclosporin A, methotrexate and the like. With the widespread use of immunosuppressive agents, their toxic side effects are increasingly exposed, and more and more immunosuppressant-related lymphomas are reported. This article reviews the immunosuppressive agents in the treatment of IBD and lymphoma, the possible mechanism and immunosuppressive agents for clinical treatment.