自七十年代以来,在抗高血压药物的选用方面取得不少经验,也提出了很多新的见解。现仅就选用抗高血压药物时应该注意的几个问题作一概述。一、首剂综合征高血压患者首次使用某种抗高血压药物时可产生心悸、晕厥等不良反应,即称首剂综合征。有代表性的药物是(口派)唑嗪。Graham等认为首剂综合征可能与体内钠盐消耗或饮食中限盐有关。(口派)唑嗪治疗高血压的剂量一般开始用0.5～1mg,2～3/d,以后逐增。此药具有与剂量相关的最大作用坪值,通常超过20mg/d的剂量即不再增加疗效。多数患者适用每日两次的给药方案。另外.在剂量增加太快或 Since the 1970s, a lot of experience has been gained in the selection of antihypertensive drugs, and many new opinions have also been put forward. Now only on the selection of anti-hypertensive drugs should pay attention to several issues to be outlined. First, the first dose of systolic blood pressure in patients with antihypertensive drugs for the first time can produce heart palpitations, syncope and other adverse reactions, that is, the first dose syndrome. A representative drug is (oral) azathiazole. Graham so that the first dose of the syndrome may be related to the consumption of sodium or salt diet. (Mouth) azadiazine dose of hypertension generally start with 0.5 ~ 1mg, 2 ~ 3 / d, then by increasing. The drug has a dose-related maximum effect plateau, usually more than 20mg / d dose that no longer increase the efficacy. Most patients apply daily dosing regimen. In addition, the dose increases too fast or