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瘦素是肥胖基因编码的一种蛋白质产物,通过与其受体结合而发挥广泛的生物学效应。近年来的大量研究显示,瘦素与冠心病发生、发展密切相关,其促冠心病发生、发展的机制尚不明确,可能通过参与炎性反应、加剧脂代谢紊乱、诱导氧化应激、引起内皮细胞功能紊乱、促进新生血管形成、刺激血管平滑肌细胞增值迁移、增加泡沫细胞形成、促动脉粥样硬化、加强血小板聚集、诱发血栓形成和增加交感神经兴奋性等多种机制影响冠心病的发生和发展。
Leptin is a protein product encoded by obese genes that exerts a wide range of biological effects by binding to its receptors. In recent years, a large number of studies have shown that leptin and coronary heart disease is closely related to the occurrence and development of coronary heart disease, its mechanism is not yet clear, may be involved in inflammatory reaction, aggravate lipid disorders, induce oxidative stress, causing endothelial Various mechanisms such as cell dysfunction, promoting neovascularization, stimulating the proliferation and migration of vascular smooth muscle cells, increasing the formation of foam cells, promoting atherosclerosis, enhancing platelet aggregation, inducing thrombosis and increasing sympathetic excitability affect the occurrence of coronary heart disease development of.