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目的:研究得力生注射液对紫杉醇药动学的影响。方法:测定16只SD大鼠单用紫杉醇及合用得力生注射液后紫杉醇的血药浓度,并进行药动学参数的计算和比较。结果:与单用比较,合用得力生注射液后紫杉醇分布相半衰期t_(1/2α)明显减小[(1.62±0.54)和(0.14±0.07)h,(P<0.05)];t_(1/2β)、CL、AUC_((0-τ))、AUC_((0-∞))、C_(max)差异无统计学意义(P>0.05)。结论:在大鼠体内得力生注射液可能影响紫杉醇的药动学,使紫杉醇分布相半衰期t_(1/2α)明显减小。
Objective: To study the effect of Tellus injection on pharmacokinetics of paclitaxel. Methods: The plasma concentrations of paclitaxel in 16 Sprague-Dawley rats treated with paclitaxel alone and in combination with Tel-Sheng Injection were determined and the pharmacokinetic parameters were calculated and compared. Results: Compared with single use, the half life of paclitaxel (t 1/2) was significantly reduced (1.62 ± 0.54 and 0.14 ± 0.07 h, P <0.05), t_ (1) / 2β), CL, AUC_ (0-τ), AUC_ (0-∞)) and C_ (max) were not statistically significant (P> 0.05). CONCLUSION: Telmisartan injection in rats may affect the pharmacokinetics of paclitaxel, and the half-life of paclitaxel, t 1/2 (1/2), is significantly reduced.