论文部分内容阅读
目的探讨胃癌组织中c-Met、AKT和血管内皮生长因子(VEGF)的表达及意义。方法应用免疫组织化学法检测70例胃癌组织中c-Met、AKT和VEGF的表达,并分析其与临床病理特征的相关性。结果胃癌组织中c-Met、AKT和VEGF阳性表达率分别为21.4%(15/70)、37.1%(26/70)和11.4%(8/70)。c-Met表达与胃癌远处转移有关(P<0.05);AKT表达与胃癌分化程度、TNM分期、淋巴结转移、远处转移相关(P<0.05或P<0.01);而VEGF表达与胃癌分化程度相关(P<0.01)。c-Met与AKT和VEGF在胃癌组织中的表达呈正相关(r=0.319和r=0.250,P<0.01)。结论 c-Met、AKT和VEGF在胃癌中的阳性表达与胃癌的生物学行为密切相关。c-Met、AKT和VEGF之间可能存在协同作用,共同促进了胃癌的恶性发展。
Objective To investigate the expression and significance of c-Met, AKT and vascular endothelial growth factor (VEGF) in gastric cancer. Methods The expressions of c-Met, AKT and VEGF in 70 cases of gastric cancer tissues were detected by immunohistochemistry. The correlations between them were analyzed with clinicopathological features. Results The positive rates of c-Met, AKT and VEGF in gastric cancer tissues were 21.4% (15/70), 37.1% (26/70) and 11.4% (8/70), respectively. The expression of c-Met was correlated with the distant metastasis of gastric cancer (P <0.05). The expression of AKT was correlated with the differentiation of gastric cancer, TNM stage, lymph node metastasis and distant metastasis (P <0.05 or P <0.01) Related (P <0.01). There was a positive correlation between the expression of c-Met and AKT and VEGF in gastric cancer (r = 0.319 and r = 0.250, P <0.01). Conclusion The positive expression of c-Met, AKT and VEGF in gastric cancer is closely related to the biological behavior of gastric cancer. There may be a synergistic effect between c-Met, AKT and VEGF, which together promote the malignant development of gastric cancer.