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目的:探讨羟苄羟麻黄碱联合用药诱发急性肺水肿的相关风险因素。方法:按联合用药情况将使用羟苄羟麻黄碱治疗的先兆早产及早产病例287例分为4组:A组160例,单纯使用羟苄羟麻黄碱;B组39例,使用羟苄羟麻黄碱+红细胞悬液;C组62例,使用羟苄羟麻黄碱+25%白蛋白;D组26例,使用羟苄羟麻黄碱+硫酸镁。比较各组的血氧饱和度、呼吸频率、心率用药前后的差值和急性肺水肿发生率的差异。结果:①与A组相比,B组用药前后呼吸频率、心率的差值比较,差异均有统计学意义(P<0.001);用药前后血氧饱和度的差值和肺水肿的发生率比较,差异无统计学意义(P>0.05)。②与A组相比,C组用药前后血氧饱和度、呼吸频率、心率的差值和肺水肿发生率,差异均无统计学意义(P>0.05)。③与A组相比,D组用药后血氧饱和度、呼吸频率、心率的差值,差异均有统计学意义(P<0.001),两组肺水肿发生率比较,差异均有统计学意义(P=0.005)。结论:静脉滴注羟苄羟麻黄碱时,联合应用硫酸镁可增加发生急性肺水肿的风险,应禁止两者联合用药。
Objective: To investigate the related risk factors of acute pulmonary edema induced by combination of oxybenzal and ephedrine. Methods: 287 cases of threatened preterm labor and premature labor treated with oxybenzalgin ephedrine were divided into 4 groups according to the combination therapy: 160 cases in group A were treated with oxybenzone alone; 39 cases in group B were treated with hydroxybenzaloxamine Alkaline + erythrocyte suspension; C group 62 cases, the use of hydroxybenzaldehyde ephedrine + 25% albumin; D group 26 cases, the use of hydroxybenzaldehyde ephedrine + magnesium sulfate. The differences of the oxygen saturation, respiration rate, heart rate before and after treatment and the incidence of acute pulmonary edema were compared between the groups. Results: ①Compared with group A, the differences of respiratory rate and heart rate before and after treatment in group B were statistically significant (P <0.001); The difference of the blood oxygen saturation and the incidence of pulmonary edema before and after treatment , The difference was not statistically significant (P> 0.05). ② Compared with group A, the differences of oxygen saturation, respiratory rate, heart rate and incidence of pulmonary edema before and after treatment in group C were not statistically significant (P> 0.05). ③Compared with group A, the difference of oxygen saturation, respiration rate and heart rate in group D after treatment was statistically significant (P <0.001). There was significant difference in the incidence of pulmonary edema between two groups (P = 0.005). Conclusion: Intravenous injection of hydroxybenzalpha, the combined use of magnesium sulfate can increase the risk of acute pulmonary edema, the combination of both should be banned.