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1985年Backlund等首次应用自体肾上腺髓质为人帕金森病患者行脑内移植手术,目前已逾200例.约半数患者虽暂时见有某种效果,但长期观察几乎未能证实成活的嗜铬细胞.肾上腺髓质嗜铬细胞不仅有产生儿茶酚胺功能,而且含有神经节甙酯(ganglioside)、成纤维细胞生长因子(FGF)等多种营养因子,所以如何提高成活率仍是目前该移植方法的重要课题.体外实验表明,嗜铬细胞在无皮质类固醇存在下或添加神经生长因子(NGF)可延长突触,并向神
Backlund and other first time in 1985, the application of autologous adrenal medulla in patients with Parkinson’s disease in patients with intracerebral transplants, there are more than 200 cases.About half of patients temporarily see some effect, but long-term observation almost failed to confirm the survival of chromaffin cells Adrenal medullary chromaffin cells not only produce catecholamines, but also contain ganglioside, fibroblast growth factor (FGF) and other nutritional factors, so how to improve the survival rate is still important for the transplant method In vitro experiments showed that chromaffin cells in the absence of corticosteroids or the addition of nerve growth factor (NGF) can extend the synapses, and to God