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目的:探讨普米克令舒雾化吸入对儿童哮喘的治疗效果及对IL-1β和IL-12水平的影响。方法:选取2012年1月~2013年10月哮喘患儿168例,对照组82例采用常规治疗,观察组86例在常规治疗基础上应用普米克令舒雾化吸入治疗。观察两组疗效、主要症状、体征、气道阻力并测定IL-1β和IL-12水平。结果:观察组治愈率为75.59%,高于对照组的62.20%(P<0.05);观察组咳嗽、喘息和肺内哮鸣音评分为(3.04±0.03)分、(3.11±0.03)分和(3.12±0.04)分,明显低于对照组(P<0.05);治疗后观察组气道阻力为(1.74±0.11)kPa/L、低于对照组(2.28±0.14)kPa/L(P<0.05);两组治疗后IL-1β和IL-12均低于治疗前(P<0.05);观察组治疗后IL-1β和IL-12分别为(19.18±1.39)ng/L和(23.38±2.04)ng/L,均低于对照组的(34.26±1.42)ng/L和(46.27±2.16)ng/L(P<0.05);Western blot检测发现,普米克令舒组IL-1β和IL-12灰度值分别为0.354±0.059,0.579±0.051,与哮喘组相比具有统计学差异(P<0.05)。结论:普米克令舒雾化吸入治疗儿童哮喘具有显著的临床效果,并可减低患儿血清中IL-1β和IL-12水平。
Objective: To investigate the therapeutic effect of pulmicort respiration inhalation on asthma in children and its effects on the levels of IL-1β and IL-12. Methods: 168 children with asthma from January 2012 to October 2013 were selected, and 82 patients in the control group were treated by conventional therapy. The observation group was treated with pulmicort respiration inhalation therapy on the basis of routine treatment. The curative effect, main symptoms, signs and airway resistance of the two groups were observed and the levels of IL-1β and IL-12 were measured. Results: The cure rate in the observation group was 75.59%, which was higher than that in the control group (62.20%, P <0.05). The scores of cough, wheezing and pulmonary wheeze in the observation group were (3.04 ± 0.03) and (3.11 ± 0.03) (3.12 ± 0.04), which was significantly lower than that of the control group (P <0.05). After treatment, the airway resistance of the observation group was (1.74 ± 0.11) kPa / L, which was lower than that of the control group (2.28 ± 0.14) kPa / L 0.05). The levels of IL-1β and IL-12 in the two groups after treatment were lower than those before treatment (P <0.05). The levels of IL-1β and IL-12 in the observation group were (19.18 ± 1.39) ng / L and 2.04 ng / L, both of which were lower than those in the control group (34.26 ± 1.42 ng / L and 46.27 ± 2.16 ng / L, P <0.05). Western blot showed that the levels of IL-1β and IL -12 gray-scale values were 0.354 ± 0.059,0.579 ± 0.051, compared with the asthma group was statistically significant (P <0.05). Conclusion: Pulmicort respiration inhalation treatment of children with asthma has a significant clinical effect, and can reduce serum IL-1β and IL-12 levels.