论文部分内容阅读
比较了批式反应器和连续流动搅拌反应器（CSTR）中酶动力学拆分萘普生的不同之处．从宏观反应器平衡角度，推导出了在CSTR中不同于在批式反应器中的酶立体选择性（E）、产物对映体过量值（eep）和反应转化率（ξ）的定量关系式．并通过脂肪酶催化的萘普生甲酯的不对称水解反应得到了证实．分别在CSTR和批式反应器中进行萘普生的酶法拆分，在一定的转化率下，从批式反应器中得到的产物的对映体过量值高于CSTR反应器的结果；相同条件下，批式反应器中的转化率也高于CSTR反应器中．连续操作1200h，批式反应器中剩余酶活力为65％，CSTR中剩余酶活力为80％，CSTR中酶的操作稳定性优于批式反应器．
The differences between enzymatic resolution of naproxen in batch reactors and continuous flow stirred reactors (CSTRs) were compared. From the perspective of macroscopic reactor balance, the quantitative relationship between the enzyme stereoselectivity (E), the product enantiomeric excess (eep) and the reaction conversion rate (ξ) in the CSTR differs from that in the batch reactor . The asymmetric hydrolysis of naproxen methyl ester catalyzed by lipase was confirmed. The enzymatic resolution of naproxen was carried out in CSTR and batch reactors, respectively. The enantiomeric excess of the product obtained from the batch reactor at a certain conversion was higher than that of the CSTR reactor; the same Under the conditions, the conversion rate in the batch reactor is also higher than that in the CSTR reactor. The continuous operation of 1200h, Batch Reactor remaining enzyme activity was 65%, CSTR residual enzyme activity was 80%, CSTR enzyme operation stability is better than the batch reactor.